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ABSTRACT
This study sought to equip clinician’s on the imaging modality of choice between CT and MRI in the diagnosis of brain tumor. The comparison of the two imaging modalities was accessed using biopsy as goal standard. This research study involved 40 patients who underwent CT, MRI and biopsy one at a time in National hospital, Abuja. Data were collected via secondary source using patient’s folder; hospital records. The result revealed that MRI which has an accuracy, sensitivity and specificity of 67.5%, 65.22% and 70.65% respectively is more accurate than CT which had a sensitivity and specificity of 15%, 13.04% and 17.65% respectively in the diagnosis of brain tumour. Knowledge of the clinician on which modality of choice to use is evaluated.
TABLE CONTENT
Title page
Approval page
Certification
Dedication
Acknowledge
List of tables
Abstract
Table of content
Chapter One
1.1 Introduction
1.2 Statement of problem
1.3 General objective
1.4 Specific objective
1.5 Hypothesis
1.6 Significance of study
1.7 Scope of study
1.8 Literature review
Chapter Two
2.1 CT and its principles of operation
2.2 MRI and its principles of operation
2.3 Anatomy and physiology of the brain
2.4 Pathophysiology of brain tumuor
2.5 Conditions that mimic Brain tumour
2.6 Cause, symptoms and types of Brain tumour
2.7 How CT of the brain is done and clinical presentation of Brain
tumour on CT radiograph
2.8 How MRI of the brain is done and clinical presentation of
Brain tumour MRI radiograph
Chapter Three
3.0 Design of the study
3.2 Population
3.2.1 Area of study
3.2.2 Target population
3.2.3 Subject selection criteria
3.3 Method of data collection
3.3.1 Equipments
3.3.2 Procedure for data collection
3.4 Data analysis
Chapter Four:
Data Presentation
Chapter five: Discussion, Recommendations,
Summary of Findings and Conclusion
5.1 Discussion
5.2 Summary of findings
5.3 Recommendations
5.4 Conclusion
5.5 Areas of further studies
5.6 Limitations of the study
References
Appendix
CHAPTER ONE
1.1 INTRODUCTION
Brain tumours are abnormal and uncontrolled proliferation of cells1. Some originate in the brain itself, in which they are termed primary. Others spread to this location from somewhere else in the body through metastases and are termed secondary.
Primary brain tumours do not spread to other body sites, and can be malignant or benign. Secondary brain tumours are always malignant. Because the space inside the skull is limited, their growth increase intracranial pressure, and may, cause edema, reduced blood flow, and displacement with consequent degeneration, of healthy tissue that controls vital function.2
Any brain tumor is inherently serious and life-threatening because of its invasive and infiltrative character in the limited space of the intracranial cavity3. However, brain tumors (even malignant ones) are not invariably fatal, especially lipomas which are inherently benign.
Brain tumors or intracranial neoplasms can be cancerous (malignant) or non-cancerous (benign); however, the definitions of malignant or benign neoplasms differ from those commonly used in other types of cancerous or non-cancerous neoplasms in the body. Its threat level depends on the combination of factors like the type of tumor, its location, its size and its state of development.
Because the brain is well protected by the skull, the early detection of a brain tumor only occurs when diagnostic tools are directed at the intracranial cavity. Usually detection occurs in advanced stages when the presence of the tumor has caused unexplained symptoms.
A good evaluation of the patient with a suspected brain tumour needs a complete history, exact physical examinations especially neurologic ones, and suitable diagnostic neuroimaging studies. The differential diagnosis of patients with signs and symptoms of brain tumours includes both neoplastic and non-neoplastic conditions.4
Computed tomography is the most widespread diagnostic tool for the localization and staging of brain tumour. It has an advantage of being widely available. Computed tomography is faster than magnetic resonance imaging making it study of choice in cases of trauma and emergencies.
MRI provides detailed info about brain tumour anatomy, cellular structure and vascular supply, making it an important tool for effective diagnosis, treatment and monitoring of brain tumour5. MRI does not use ionizing radiation, and thus preferred over CT in patient requiring multiple imaging examinations.
1.2 STATEMENT OF PROBLEM
Most patients undergo both the CT and MRI as radiological investigation for the diagnosis of brain tumour. This however could be prevented if the referring clinician knew which modality is better in terms of diagnostic quality.
1.3 GENERAL OBJECTIVE
The aim of this study is to compare the diagnostic quality of computed tomography and magnetic resonance imaging.
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